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KMID : 0350519930460010277
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Journal of Catholic Medical College
1993 Volume.46 No. 1 p.277 ~ p.283
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The Effect of Recombinant Human Growth Hormone on Thyroid Function in Nformal Children
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Abstract
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Administration of human growth hormone to normal men and growth hormone deficient patients yield conflicting results concerning its impact on thyroid function. Most studies have casuistic or uncontrolled and have used pituitary derived growth hormone of
varying purity, often contaminated with thyroid stimulating hormone.
The aim of the present study was to evaluate the effects of recombinant human growth hormone on thyroid function in normal chidren.
All 15 nomal variant short stature chidren with aged 4.5-10.3 year had normal serum level of growth hormone and were taking no medications at the time of study. All children received recombinant human growth hormone in a dose of 0.25IU/kg/day
subcutaneously for 5 days.
Blood samples were obtained before the first injection and 24 hours after last injection of growth hormone and the serum was frozen at -20℃for later analysis. Serum T4, T3, reverse T3, TSH and IGF-I concentration was measured by a radilimmunoassay.
1. The mean serum T4 concentration decreased significantly from 9.28±0.55㎍/dl to 1.21±0.38㎍/dl.
2. The mean serum free T4 concentration decreased significantly from 1.49±0.008 ng/dl to 1.21±0.07 ng/dl.
3. The mean serum T3 concertration increased significantly from 1.46±0.06 ng/ml to 1.88±0.10 ng/ml.
4. The T3 to T4 ratio inreased significantly from 16.3±0.9 to 25.3±1.8.
5. The mean serum reverse T3 concentration was not changed significantiy.
6. The mean serum TSH concentration decreased significantly from 2.13±0.21μIU/ml to 1.50±0.14μIU/ml.
7. The mean serum IGF-I concentration increased significantly from 165±30 ng/ml to 349±47 ng/ml.
In conclusion, our data suggest growth hormone enhance the peripheral conversion of T4 to T3 and compensatory decrease in TSH secretion.
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